RNA Details
Disease Name
cicatrix hypertrophic
Tissue
skin
RNA Symbol
mir-130a
RNA ID
RNA Type
miRNA
Alteration Pattern
dysregulation
Species
mus musculus
Detection Methods
qRT-PCR; dual-lucimmunofluorescenceerase reporter assay etc.
Target
CYLD
Pathway
MIR-130A; CYLD; PI3K-AKT SIGNALING PATHWAY
PubMed ID
Title
MicroRNA-130a has pro-fibroproliferative potential in hypertrophic scar by targeting CYLD
Year
2019
Function
"Our results indicate that mir-130a promotes collagen secretion, myofibroblast transformation and cell proliferation by targeting cyld and enhancing akt activity. Therefore, the mir-130a;Cyld;Akt pathway may serve as a novel entry point for future skin fibrosis research."